That finding raises the hope that leptin may help reverse insulin resistance in people and help ward off diabetes.Ī potbelly is also associated with a greater risk of developing heart disease. In Rossetti's study, leptin significantly enhanced the effects of insulin. People with insulin resistance, in turn, run a greater risk of developing diabetes. People with an apple-shaped body, in which fat is deposited mostly around the waist instead of on the thighs or hips, are known to run a greater risk of insulin resistance, a condition in which cells don't respond effectively to insulin's message to take up sugar from the bloodstream. "That was a pretty striking phenomenon," Rossetti told Science News. However, the animals lost more fat from their abdomens than from other parts of their bodies. ![]() As expected, the rats ate less and lost weight. Rossetti's team gave moderately obese rats an infusion of leptin for 8 days. Now, endocrinologist Luciano Rossetti of the Albert Einstein College of Medicine in New York and his colleagues have published a study of rats that suggests leptin may play a role in diseases associated with a fat abdomen, the spare tire that many people develop as they grow older. Researchers have been racing to unlock leptin's secrets since its discovery in 1994 (SN: 12/3/94, p. New research suggests that the cure for a tubby tummy may be leptin, a hormone thought to play a role in regulating body fat.
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